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Lipinska et al., 2025), EVs have been applied using heterogeneous experimental protocols, with doses generally ranging from low g/mL concentrations (310 g/mL) to higher fixed doses around 120200 g/mL, and exposure times spanning from short co-culture periods of a few hours (up to 14 h) to prolonged treatments covering complete in vitro maturation windows according to the specie (approximately 1838 h)

Initiation of membranal lipid peroxidation by activated metmyoglobin and methemoglobin

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It also did not reflect any developmental, genetic, or allergic side effects