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When ERS occurs, GRP78 binds to misfolded proteins and dissociates from PERK, IRE1, and ATF6, activating downstream signaling pathways to inhibit DNA transcription and translation, prevent protein synthesis, and accelerate the degradation of aberrant proteins, thus regulating the adaptation of the intracellular environment

Whether that reshuffling translates into anything functional, real changes in how a cell ages, behaves, or secretes, is a separate question each study has to test on its own terms

Dietary habits were evaluated using a questionnaire of food frequency

Such homeostasis modulates apoptosis, bioenergetics, cell growth, and inflammatory responses [28,45]