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Loneliness is Associated with Other Diseases Too Other studies that are just as robust, but perhaps fail to grab the headlines in the same way, have likewise shown a range of health conditions associated with loneliness and social isolation, including heart disease and stroke, type 2 diabetes, rheumatoid arthritis, and cancer (2 Trusted Source Loneliness and social isolation as risk factors for coronary heart disease and stroke: systematic review and meta-analysis of longitudinal observational studies Go to source)