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The guanidinoacetate released by the kidneys is methylated by guanidinoacetate N-methyltransferase, which is mainly found in the liver, pancreas, and to a very small extent in the kidneys, and produces creatine [36]

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Kidney amino acid metabolism contributes to gluconeogenesis, nitrogen clearance, acidbase metabolism and provision of fuel for tricarboxylic acid cycle and urea cycle intermediates, and is thus a central hub for homeostasis