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The total rhGH dose delivered to the adolescents with ISS was 21 mg/kg in the rhGH group and 35 mg/kg in the rhGH + A group, respectively
This heterogeneity is well captured by a recent meta-analysis of 29 studies, which reported significant increases in follicle numbers and ovarian hormone levels following MSC-derived EV administration, but also highlighted a wide range of administered doses (approximately 10400 g per dose or 10 6 10 12 particles), treatment schedules spanning from single injections to repeated administrations over days or weeks, and variable timing of outcome assessment relative to POI induction ( Additional in vivo studies further exemplify this diversity
Deficiency results in fatigue, weakness, and cognitive fog
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