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Several approaches have been explored to enhance maturation of HLCs, including the formation of tissue-like 3D spheroids or organoids, use of extracellular matrix (ECM)-based hydrogels or scaffolds, coculture with endothelial cells or other hepatic cells, the addition of small molecules uncovered by screening, and overexpression of certain transcription factors, all of which are reviewed elsewhere (46)

Tesamorelin is known to increase IGF-1 and IGFBP-3

Functional Variants in the Glutathione Peroxidase-1 (GPx-1) Gene Are Associated with Increased Intima-media Thickness of Carotid Arteries and Risk of Macrovascular Diseases in Japanese Type 2 Diabetic Patients

(Isolated vitamin B12 deficiency is very rare)