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The influence of smoking as a determinant of overall health inequalities is such that, if the entire population was non-smoking, mortality differences between social groups would be halved." 18

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For example, despite the evidence for a common underlying liability model having replaced the unproven gateway theory, possible causal gateways have increased in importance despite as yet unproven hypothetical fears that ANDS will lead more youth to become combustible users than otherwise would be the case [50, 51]