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Cell culture studies using adipocytes have shown that NNMT overexpression promotes lipid accumulation and insulin resistance, while NNMT knockdown or inhibition increases NAD+ levels, activates SIRT1, enhances mitochondrial respiration, promotes expression of thermogenic genes including UCP1, and drives white adipocyte browning toward a beige phenotype

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Limited evidence suggests that non-starchy vegetables may DECREASE the risk of: Estrogen receptor-negative (ER-) breast cancer Limited evidence suggests that non-starchy vegetables and fruits combined may DECREASE the risk of: Bladder cancer Ongoing Areas of Investigation Laboratory Research Flavonols (such as the quercetin in asparagus) influence gene expression and cell signaling in ways that increase antioxidant, anti-inflammatory and carcinogen-deactivating enzymes in studies of isolated cells and limited animal studies