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Inflammation, whether from acne, skin injuries, or other forms of trauma, can stimulate an increase in melanin as part of the skins natural healing process

Wiley Online Library,pp

Under the excessive accumulation of reactive oxygen species (ROS), over-oxidized PUFA-containing phospholipids (PUFA-PLs) alter the membrane structure and increase its permeability, eventually leading to plasma membrane rupture and cell damage [8]