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It may be an important early step in the process that results in addiction. The combination of effectsincreasing dopamine release and decreasing the inhibitory [GABA] responseresults in an amplification of the rewarding properties of nicotine It would be difficult to design a better drug to promote addiction. Nicotine is MORE addictive than heroin, because it affects BOTH sides of your brainand its why you havent quit, yet Nicotine, therefore, has a combination effect of INCREASING dopamine release while DECREASING inhibitory GABA response

Nicotine & Tobacco Research, 2017

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