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GPX3 overexpression inhibits microglial pyroptosis and reduces NLRP3 and GSDMD-N expression 57

Those most at risk include vegans and vegetarians, people with digestive conditions such as Crohn's disease, coeliac disease or IBS, those taking long-term metformin or proton pump inhibitors, older adults whose ability to absorb B12 through the gut declines naturally with age, those with pernicious anaemia, and anyone with a history of chronic alcohol use

Zou H, Henzel WJ, Liu X, Lutschg A, Wang X

Ceramide biosynthesis involves the conversion of serine and palmitoyl-CoA to 3-dehydrosphinganine, which is a substrate for the enzyme 3-dehydrosphinganine reductase