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Sample layout example: Lanes 1-6 for GSSG concentration measurement and lanes 7-12 for total glutathione concentration measurement Q How to measure a sample blank if the sample is colored A If the sample has coloration, the sample blank can be subtracted by either of the following two methods

The most emblematic example is bitopertin (RG1678), which initially demonstrated efficacy in phase II trials for schizophrenia negative symptoms yet failed to meet primary endpoints in multiple phase III trials (Umbricht et al

[DOI] [PubMed] [Google Scholar] 161.Nahrwold DL, Rose RC, Ward SP

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