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Identification of RAPL as a major effector of RAP1 responsible for delivering both RAP1 and LFA1 to the lymphocyte membrane of migrating cells and to the immunological synapse

427 Moreover, lung microbiome selectivity, such as cough, mucociliary clearance, and host immune defense mechanisms, is often impaired in critically ill patients as a result of both the disease itself and pharmacological interventions (e.g., sedation and corticosteroids)

Metabolic dysregulation in microglia impairs A clearance and sustains proinflammatory cytokine release (136)

Getting the dose right matters enormously, and small errors compound over weeks and months of treatment