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For confirmed deficiency or pernicious anaemia, NICE Clinical Knowledge Summaries recommend hydroxocobalamin 1mg intramuscularly, with frequency determined by the underlying cause and neurological involvement

Additionally, a high dosage of EPA (1.8 g/d) for 12 weeks could improve the psychological symptoms, and quality of life by alleviating the severity, frequency and disability of migraine attacks (135)

It helps maintain mitochondrial membrane potential and prevent the release of pro-apoptotic factors from mitochondria, thereby preserving cell viability (Pang, 2015)

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