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The p38 goes from the cytosol to the nucleus after activation, where they activate downstream transcriptional targets such as PAX6, ETS1, PRAK, MK3, RAR, AP-1, ATF1, and CHO to control cellular processes (144) It is generally believed that overactivation of the MAPK/ERK signaling pathway is positively related to chemoresistance

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Depletion of vitamin E increases amyloid beta accumulation by decreasing its clearances from brain and blood in a mouse model of Alzheimer disease

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