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PR-A and PR-B are two main isoforms of nuclear PR, which differ in structure and function

In longer-term cell culture or standardized animal model studies, changes in transporter expression, mitochondrial adaptation, substrate preference, or gene expression may occur as indirect consequences of altered metabolic state, but those effects should not be described as a direct receptor-mediated transcriptional program unless the mechanism has been specifically demonstrated in the tested model

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Contributes to the protection of the skin from UV damage, preventing photoaging and hyperpigmentation especially in areas with a high risk of sun exposure Clin Dermatol