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It doesnt answer the long-term safety question
Notably, in contrast to 23 (HA08), a structurally very similar epimer (HA09) which differs only with regard to one stereogenic center and exhibiting a 100-fold lower affinity to IRAP did not affect spine morphology, indicating a correlation between the capacity to inhibit IRAP and a positive impact on DSD and spine morphology
It is a small synthetic molecule that blocks an enzyme called NNMT (nicotinamide N-methyltransferase)
