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However, the exact intracellular mechanism that contributes to inducing this oxidative stress is not completely understood ( Iron has been discovered to play a part in APAP-caused hepatotoxicity

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This model describes MCT1 existing in an open and closed conformation, with the N- and C-terminal halves tilting against each other along an axis that separates the two domains, allowing the substrate binding site alternating access to the either side of the membrane (Wilson et al

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