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Some early studies in animals have shown a potential risk to foetal development, which is why current advice is to avoid use in pregnancy and stop treatment well in advance of trying to conceive

Secondary outcomes Five included studies comprising 3605 patients reported change in MCV, four studies comprising 140 patients reported change in homocysteine levels, four studies comprising 3588 patients reported change in platelets count, and only three studies with 3430 patients reported change in WBC count