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During the review, the committee will likely consider: The extensive body of published research on GHK-Cu (decades of studies) Safety data for both injectable and topical routes The clinical rationale for copper peptide therapy in anti-aging and wound healing Quality control considerations for compounding GHK-Cu formulations Public comments from patients, dermatologists, anti-aging practitioners, and pharmacies Given GHK-Cu's long history of use and substantial research base, many in the peptide therapy community are cautiously optimistic about a positive PCAC recommendation particularly for the topical route

It has been found that MELAS results from the A3243G mtDNA mutation which appears to be linked to autism [83]

Color figures are included in the HTML version of this manuscript Additional information Edited by A Finazzi-Agro Supplementary Information accompanies the paper on Cell Death and Differentiation website ( Supplementary information Rights and permissions About this article Cite this article Franco, R., Cidlowski, J