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Quarta, C., Snchez-Garrido, M

Studies have shown that DAP and reuterin can inhibit the heterodimerization of HIF-2 with the aryl hydrocarbon receptor nuclear translocator, thereby downregulating the expression of intestinal iron absorption-related genes and subsequently limiting iron uptake (51)

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569 FXR agonists are most often combined with other agents in the treatment of NASH to minimize side effects and to increase the likelihood of success by targeting different metabolic pathways