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For people who suffer from liver problems such as hepatitis, fatty liver, or whove damaged their liver through excessive alcohol intake, milk thistle is regarded as one of the best natural treatments for these issues

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The downstream effects of RAGE-induced ROS in rat mesangial cells include reduced levels of the antioxidant transcription factor nuclear factor erythroid 2-related factor 2 (NRF2) (50) and increased activation of phosphoinositide 3-kinase (PI3K)/AKT pathway, which leads to activation of nuclear factor (NF)-B and the production of pro-inflammatory cytokines (51)

Hunter RW, Lawson C, Galitsiou E, Gifford F, Neary JJ