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Abstract Purpose of review: To provide an overview of the underlying neurobiology of tobacco smoking in schizophrenia, and implications for treatment of this comorbidity

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The study observed a modest but significant reduction in stroke risk at 5 years in favor of atorvastatin (2.2% absolute and 16% relative risk reductions).14 Those patients who achieved a 50% reduction in LDL-cholesterol level had the most benefit (38% relative reduction in stroke risk) followed by those who achieved an LDL-cholesterol level of less than 70 mg/dL (28% relative risk reduction).15 Although potency varies by statin drug, with rosuvastatin and atorvastatin considered the most potent (capable of achieving greater than 50% LDL-cholesterol level lowering at medium to high doses), choice of statin may be determined by other factors, including costs and patient tolerance