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In contrast, animals with total IGF-I deletion or only peripherally produced IGF-I deletion showed marked growth retardation (79)

They also activate resident cells in the lung, particularly epithelial cells and alveolar macrophages, to generate chemotactic molecules that recruit neutrophils, monocytes and lymphocytes into the lung

Annu Rev Cell Dev Biol 30(1):255289 Coumans FAW, Brisson AR, Buzas EI, Dignat-George F, Drees EEE, El-Andaloussi S, Emanueli C, Gasecka A, Hendrix A, Hill AF, Lacroix R, Lee Y, van Leeuwen TG, Mackman N, Mger I, Nolan JP, van der Pol E, Pegtel DM, Sahoo S, Siljander PRM, Sturk G, de Wever O, Nieuwland R (2017) Methodological guidelines to study extracellular vesicles

The peptide's gastric stability further enables oral-administration designs that are not feasible with most peptide research compounds