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Handling: Research use only (RUO)

The synergy emerges because MOTS-c increases demand for NAD+-dependent processes while 5-Amino-1MQ increases NAD+ supply

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Another mechanism by which the endo/lysosomal compartment can influence APAP-induced hepatotoxicity is through the clearance of damaged mitochondria in a process also called mitophagy, consisting in the degradation of dysfunctional mitochondria by lysosomal proteases upon fusion of the autophagosomes-containing mitochondria with lysosomes, which is discussed in the next section