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Research indicates that individuals with BP-I remain symptomatic for nearly half of their illness course, with depressive symptoms being the most frequent and persistent, significantly outweighing manic/hypomanic and mixed episodes (Nierenberg et al., 2023)

However, these studies are still limited to lab only, and cant be directly applied to human use

[121] Age is also a contributing factor: elderly individuals are often achlorhydric due to reduced parietal cell function in the stomach, increasing their risk of vitamin B 12 deficiency

Its antioxidant properties can help neutralize inflammation-driven oxidative stress in the digestive tract