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Hepatocytes possess highly efficient counter-regulatory systems against oxidative effects such as cytochrome systems (CYP) P450, either by endogenous or exogenous substances, enzymes such as glutathione S transferase, the flow-through transporters, and molecules that contain thiol, such as Glutathione or Thioredoxin [68]

Motor functioning was evaluated starting at 2 weeks post-surgery and testing was conducted on a biweekly basis using a walking track analysis where the rats were made to walk in a confined walkway lined with white paper and led into a dark shelter

Table 5 Impact of CL dysfunction on early pregnancy outcomes

Hence, it has been proposed that the neurological symptoms present in the most severely affected ACAD9-deficient patients could be attributed to a deficiency in brain FAO