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These changes converge with dysregulation of spindle assembly checkpoint and cell-cycle progression regulators, including CDC20, BUB1, and MAD2L1, which collectively buffer against segregation errors [4, 104,105,106,107,108,109]

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Perhaps the best known and the most common EDC is bisphenol A, which is considered to be a selective estrogen receptor modulator, revealing unfavorable effects on reproduction [1, 9]