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Acute soft tissue injuries show the highest response rates, with approximately 60 to 70 percent of users reporting clear benefit and 30 to 40 percent describing dramatic improvement

The common ones are a little stinging, redness or swelling at the site, a small harmless lump, or occasional bruising if a tiny blood vessel is caught

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The 2018 paper in Biochemical Pharmacology gave obese mice a membrane-permeable NNMT inhibitor and reported it significantly reduced body weight and white adipose mass, decreased adipocyte size, with the mice eating the same amount as before, and the authors noting the inhibitors did not impact total food intake nor produce any observable adverse effects [1]