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In the Phase 2 dose-finding trial, men and women receiving cagrilintide 4.5 mg achieved mean weight loss of 10.8% over 26 weeks

Hyperglycaemia further contributes to membrane rigidity through the generation of AGEs, which aggravate oxidative stress and promote free radical formation, causing damage to the lipid bilayer ( Figure 9 A second potential pathway involves the interplay between lipid dysregulation and inflammation

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