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Mineral content, collagen orientation, and protein gradients all vary throughout the length of the enthesis (Deymier-Black et al ., 2015

doi: 10.1111/j.1365-313X.2011.04853.x 8 CarvalhoF

1 Metformin: origins, chemical structure, and pharmacokinetic profile Metformin is widely recognized as the first-line oral antihyperglycemic agent for the treatment of type 2 diabetes mellitus (T2DM) globally