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10.1002/jor.20096 69 KrivicA.MajerovicM.JelicI.SeiwerthS.SikiricP
Studies show that without ongoing medication: Most patients regain 75-90% of lost weight within two years Many report unusually strong hunger signals after discontinuation Metabolic adaptation makes weight maintenance significantly more challenging Of all the potential long-term effects, bone health deserves special attention because: Bone loss occurs silently : Unlike digestive side effects that are immediately noticeable, bone loss happens gradually with no symptoms until a fracture occurs The effects can be permanent : Once significant bone loss occurs, it can be difficult to fully restore The consequences are serious : Osteoporotic fractures can lead to chronic pain, disability, and in the case of hip fractures, a 20-30% mortality rate in the first year Combination risk factors : Many people taking GLP-1 medications already have other risk factors for osteoporosis, creating a perfect storm for bone health problems Also read: Does Ozempic Cause Osteoporosis
The advisory panel was recently overhauled, and many of the new members have ties to the peptide industry, leading to criticism about potential conflicts of interest
It all depends on perspective, McKinley said
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