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Several studies have observed an association between use and such unwanted outcomes as unemployment, living alone and feeling isolated, criminal activity and lower life satisfaction (Sherer et al., 1999

To be specific, there were 4 upregulated proteins (P01742, Q9BXG8, P06310, P19652) and 6 downregulated proteins (A0A0B4J1X8, Q9NZP8, P61604, Q01459, Q6UXB8, Q9Y5Y7) in patients with CS-induced OLK compared to healthy individuals (data unpublished), suggesting that the alteration of circulating exosomal proteins might play key roles in promoting OLK development and be considered as biomarkers for early diagnosis of OLK

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