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Both excess and deficiency of TH exacerbate oxidative stress in endotoxin-induced uveitis, primarily through enhanced generation of ROS (e.g., superoxide anions and hydroxyl radicals) by inflammatory cells

For example, a 2005 study found that NAC administration failed to raise glutathione levels in rats,36 and a 2022 study on mice suggested that it may promote the metastatic spread of certain cancers.37 While its true that animal studies don't directly translate to human outcomes, they're still important to consider when choosing a supplement meant to support your health and wellness

Liu, Y., Wang, H., Cui, Y., & Chen, N

Specifically, the inhibition of Nrf2 ubiquitination increases nuclear Nrf2 retention and ARE-Nrf2 binding affinity (Rizvi et al., 2015a)