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See comment in PubMed Commons below Am J Med Sci

Warm your hands: Use gloves or pocket warmers to maintain dexterity while handling your materials

[83] South Africa [edit] Smoking in public is banned

This raises the critical question of whether primary tumors that successfully evolve with KEAP1/NFE2L2 mutations necessitate the co-evolution of as-yet-unidentified permissive pathways, which might be leveraged for targeted therapy