Finally, pharmacological targeting of the activity of -glutamyltransferases prevents the breakdown of circulating GSH, reduces tumour cysteine levels and slows tumour growth
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The serine deprivation-dependent induction is regulated by the activating transcription factor 4 (ATF4) and can be reversed by the addition of glycine and serine, but not by other amino acids like leucine or cysteine (Hamano et al., 2020)
