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The MR analyses indicated causal associations between smoking and the risk of obstructive chronic bronchitis, cancer of the bronchus, emphysema, peripheral vascular disease, chronic airway obstruction, pneumococcal pneumonia and type 2 diabetes

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Studies of this phenomenon have shown that macrophages are activated by factors such as cigarette smoke extracts and release inflammatory mediators such as TNF-, CXCL1, CXCL8, CCL2, leukotriene (LT) B4 and reactive oxygen species (ROS), etc., which mediate the inflammatory response ( Figure 2 Macrophages have different phenotypes with different activation pathways that lead to different organismal responses

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