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By contrast, the well-documented health risks that come with smoking tobacco include that: Nicotine in tobacco smoke is highly addictive Tobacco smoke adds 173 toxic compounds to marijuana smoke Tobacco smoke contains acrolein, which is implicated in lung diseases and respiratory cancers More than 80% of lung cancers are caused by smoking tobacco Tobacco causes systemic inflammation and cellular damage from oxidative stress Tobacco smoke elevates reactive proteins that increase the risk of heart attacks and stroke Tobacco use more than triples the odds of developing Type 2 diabetes A University College London survey found another reason to avoid mixing cannabis and tobacco