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Dudek J (2017) Role of cardiolipin in mitochondrial signaling pathways

Further, an oxidative stress induced damage to the membrane of the cells which line the bile canaliculi (cells which are rich in GGT) may also contribute to the observed increase in the activity of this enzyme in plasma

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These modifications collectively address the major limitations of natural amylin - its tendency to aggregate into toxic fibrils, rapid degradation, and poor pharmacokinetic properties - while preserving and enhancing its beneficial metabolic effects