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When using dilute acetic acid (0.1% v/v) as a solvent, it can improve initial solubilization of certain peptide batches, but the solution pH should be adjusted to near-physiological range before administration to avoid tissue irritation at the injection site in animal models

Choi BD, Gedeon PC, Herndon JE, Archer GE, Reap EA, Sanchez-Perez L, et al

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