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Actinomyces (121, 122), Prevotella (123), Bacteroides (120, 124), EscherichiaShigella (125) are the main species increased, whereas Mycobacterium , Lactobacillus , Enterobacter (123), Deltaproteobacteria , and Clostridiaceae decreased (126), including CB , FP , Clostridium leptum , Clostridium cluster XlVa , Clostridium cluster XlVb , Clostridium cluster XVIII (127)
The worst commonly experienced side effects are nausea (28% at 12mg dose) and vomiting (17%), which peak during weeks 6-8
Contributes to integrated sleepstressendocrine research frameworks: Sleep quality, stress response, and hormonal balance are interdependent biological systems
It also stimulates the formation of new blood vessels (angiogenesis) through the VEGF pathway, which is how injured tissue gets the nutrients it needs to rebuild
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