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Apply this adjustor when calculating payments for expanded access use of immunotherapy and applicable clinical trial cases that group to MS-DRG 018 by multiplying the relative weight for MS-DRG 018 by the adjustor

3.4.4 Alkaloids: comprehensive miRNA biogenesis modulation Berberine targets multiple oncogenic miRNAs, including miR-21 (5070% reduction in HCT116 cells), miR-23a (2.5-fold increase in hepatoma cells), and suppression of the miR-1792 cluster in multiple myeloma