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Glutathione synthesis and maintenance require coordinated metabolic inputs, including NADPH generated through the pentose phosphate pathway, and are transcriptionally regulated by nuclear factor erythroid 2-related factor 2 (NRF2) (2224)

In order to decrease the amount of tau phosphorylation and the formation of neurofibrillary tangles, siRNA against microtubule-associated protein tau (MAPT) has been shown to have a protective effect on synapse function and neuronal survival (101)