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The functioning of this system is based on the interaction of ligands (including endogenous endocannabinoids, e.g., anandamide, but also exogenous plant derivatives - phytocannabinoids) with specific endocannabinoid receptors, CB1/2

Importantly, the polarnonpolarpolar configuration of astaxanthin enables a transmembrane orientation that stabilizes lipid bilayers and protects membrane-embedded proteins, particularly within mitochondria