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FIGURE 10 Notably, activators of SIRT1, such as metformin, have demonstrated the ability to inhibit Th17 cell differentiation and downregulate IL-17A and RORt levels by promoting STAT3 deacetylation ( In summary, our study primarily investigated the beneficial effects of GHK-Cu in UC, using a DSS-induced colitis mouse model and an in vitro co-culture system, suggesting that GHK-Cu may exert anti-inflammatory properties and its role in facilitating the repair of UC by regulating SIRT1/STAT3 signaling pathway

The traditional Mediterranean diet is characterized by a high-fat content and low carbohydrate intake, with fat contributing 35 to 45% of daily caloric intake, protein contributing 15%, and carbohydrates contributing 40 to 45%

Conversely, the D-CuP group demonstrated enhanced wound healing, leaving a residual wound area of just 9.8%, while the G/D-CuP group exhibited the most pronounced wound healing, with only 2.8% of the wound area remaining

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