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They list several potential adjustments that can preserve the amount of nicotine that reaches the participant, including using Teflon tubing or shortening the tubing length

The half-life of a drug is the amount of time it takes for the active substance in your body to be eliminated by half

74 For such a product to be exempt, FDA must determine that (1) the modification would be considered minor, (2) an SE report that demonstrates substantial equivalence would not be necessary to ensure that marketing the tobacco product would be appropriate for protection of public health, and (3) an "exemption is otherwise appropriate." 75 Before the product can be legally marketed, FDA must first grant the product an exemption from demonstrating substantial equivalence

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