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When antibiotics, particularly sulphur drugs, are used for extended periods, the normal synthesis of Folic acid in the gut will be reduced and the requirements for Folic Acid are increased.

Regulations vary, so always check UK compliance

Nevertheless, patients using insulin or sulfonylureas may require dose adjustments when initiating potent incretin-based therapy because improved glycemia and reduced caloric intake can increase hypoglycemia risk when combined with therapies that independently lower glucose

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