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1 The initiation, also called priming, corresponds to the activation of the immediate-early response genes by pro-inflammatory cytokines, such as tumor necrosis factor alpha (TNF ) 2 and interleulin-6 (IL-6) 3 that induces the G0/G1 transition of quiescent hepatocytes

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Second, the upstream signaling pathway of PLB in regulating YTHDF1 expression should be further explored to reveal its more comprehensive molecular mechanism, and the role of PLB in other cell types and systems should be investigated to comprehensively assess its potential role in the multi-system pathology of PCOS