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The spermidine synthase (EC 2.5.1.16) mediated addition of aminopropyl from decarboxylated s-adenosylmethionine led to the synthesis of triamine spermidine and, finally, spermine synthase (EC 2.5.1.22) transfers an additional aminopropyl group to form the tetramine spermine [126]

Overexpression of Nos2 promotes the secretion of tumor necrosis factor (TNF) and interleukin1 (IL1) and subsequently induces a secondary inflammatory reaction and the generation of oxygen free radicals (Foncea, Carvajal, Almarza, & Leighton, 2000

doi: 10.1074/jbc.RA119.008180 21 WickerCAHuntBGKrishnanSAzizKParajuliSPalackdharrySet al

J Neurovirol 9:399403