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Yet both proponents and opponents of legalization have overlooked the role of nicotine in leading to the use of illicit drugs and to addiction. The article is titled, A Molecular Basis for Nicotine as a Gateway Drug. The study was supported by grants from the Howard Hughes Medical Institute and the National Institutes of Health (R01 DA024001) and the National Institute on Drug Abuse (K5 DA00081)

Since Pancreatic Stellate Cells (PSCs) are key players in PF (53, 97) it is highly likely that oxidative stress induced by tobacco components and cigarette smoke could lead to their activation, eventually resulting in PF

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